| Start | Title | Airing | |
|---|---|---|---|
| 12:00am | World Class Championship Boxing Chris Eubank, Jr. vs. Liam Williams (Cardiff, UK) | ||
| 2:00am | Red Sox Extra Innings Live White Sox at Red Sox | ||
| 2:30am | Red Sox Final Live White Sox at Red Sox | ||
| 3:00am | Dining Playbook with Billy & Jenny Season 7, Episode 1 | ||
| 3:30am | Dining Playbook with Billy & Jenny Season 7, Episode 4 | ||
| 4:00am | Dirty Water TV Kings Seaport Part 2 | ||
| 4:30am | Dirty Water TV de Laposta Restaurant Newton | ||
| 5:00am | Red Sox Extra Innings Live White Sox at Red Sox | ||
| 5:30am | Red Sox Final Live White Sox at Red Sox | ||
| 6:00am | Red Sox Almanac The 1958 Season | ||
| 6:30am | Red Sox Almanac The 1959 Season | ||
| 7:00am | VSiN By The Books 4/22/2025 | LIVE | |
| 10:00am | Fight Sports: MMA EFC339: Garreth McClellan vs. Brendan Lesar (Johannesburg, South Africa) | ||
| 11:00am | Meet Boston with Billy & Jenny | ||
| 11:30am | Dining Playbook with Billy & Jenny | ||
| 12:00pm | NESN Rundown 4/22/2025 | NEW | |
| 1:00pm | NHL Quarter-Century Team Best Draft Class | ||
| 1:30pm | This is Hockey Brazil | ||
| 2:00pm | Liverpool Football Liverpool at Leicester City | NEW | |
| 4:00pm | LFC Trending Week of April 14, 2025 | NEW | |
| 5:00pm | Charlie Moore Outdoors Charlie Moore Outdoors | ||
| 5:30pm | Red Sox First Pitch Live Mariners at Red Sox | LIVE | |
| 6:00pm | Red Sox GameDay Live Mariners at Red Sox | LIVE | |
| 6:30pm | Red Sox First Pitch Live Mariners at Red Sox | ||
| 7:00pm | Red Sox GameDay Live Mariners at Red Sox | ||
| 7:30pm | Fight Sports: Grand Sumo Tokyo, Japan: Show 2 | ||
| 8:30pm | Fight Sports: Martial Arts ISKA US Open - Men's Weapons Championship | ||
| 9:00pm | The Drift 2025, Episode 4 | ||
| 9:30pm | Red Sox Extra Innings Live Mariners at Red Sox | LIVE | |
| 10:00pm | Red Sox Final Live Mariners at Red Sox | LIVE | |
| 10:30pm | Fight Sports: MMA EFC339: Garreth McClellan vs. Brendan Lesar (Johannesburg, South Africa) | ||
| 11:30pm | Fight Sports: World Championship Kickboxing Yodkhunpon Weerasakreck vs. Suzuki Hayato (#365) | ||
| Schedule published on Sat, Apr 5, 2025 8:37pm | |||
For information regarding channel listings, visit the NESN National channel listings page.
